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Elevated PSA1

What is an Elevated PSA?

Prostate-specific antigen (PSA) is a protein produced by cells of the prostate gland. The prostate gland is a small, walnut-sized gland situated between the bladder and the penis. The PSA test is a blood test that measures the level of PSA in the blood. It is a test primarily used to screen for prostate cancer in men.

A normal PSA level is considered to be 4.0 nanograms per millilitre (ng/mL) and lower. Anything above this level is considered an elevated PSA level. An elevated PSA can be a sign of prostate cancer. It can also indicate the presence of other problems such as an enlarged prostate and inflammation. Because PSA is produced by the body and can be used to detect disease, it is sometimes called a biological marker or a tumour marker.

Causes and Risk Factors for Elevated PSA

Elevated PSA levels do not necessarily mean you have prostate cancer. Studies have shown that prostate cancer can sometimes be present in men with a PSA level at or below 4.0 too. Also, a PSA level above 4.0 does not necessarily mean you have cancer. There can be different reasons for an elevated PSA level besides prostate cancer, including:

  • Older age
  • Race (African American descent)
  • Benign prostatic hyperplasia (BPH)
  • Elevated parathyroid hormone
  • Prostate injury
  • Trauma to the groin during surgery
  • Prostatitis
  • Urinary tract infection

In general, the higher a man’s PSA level, the more likely it is that cancer is present.

Indications for PSA Test

Your physician may recommend a PSA test for the following reasons:

  • To screen for prostate cancer
  • To judge the effectiveness of a prostate cancer treatment
  • If your doctor feels an abnormality in the prostate gland during a physical exam
  • To check for the recurrence of prostate cancer

Your healthcare provider may also recommend a PSA test if you have any of the following symptoms:

  • Urinary incontinence or loss of bladder control
  • Slow urine stream
  • Frequent urination
  • Trouble urinating

Preparation for the Test

PSA test does not necessarily involve any specific steps. However, you should inform your healthcare provider of the medications you are taking as some medications can cause fluctuations in PSA levels. Also, it is not advisable to have a PSA test soon after undergoing a procedure, a urinary tract infection, or surgery involving the urinary system as all of these can cause abnormal changes in PSA levels.

PSA Test Procedure

The PSA test is a simple blood test, so there is no special preparation for this procedure. The doctor takes a blood sample from your arm. In a laboratory, this sample is then exposed to the antibody that attacks PSA, and the amount of PSA is measured. The normal range is around 0 - 4 ng/mL, but the range that is considered normal does increase with age with older men often having slightly higher PSA levels than younger men.

If you are 50 years or older, your routine physical exam should also include a digital rectal examination (DRE). By performing a DRE, your doctor can feel the surface of the prostate gland and check for any growths, enlargement, or tenderness. The combination of a digital rectal examination and PSA testing can detect cancer at an early stage when your treatment options are best.

Risks and Complications

There is minimal risk with collecting a blood sample for laboratory analysis. However, veins and arteries vary in size from people to people and some may experience difficulty during the blood draw. Some of the risks of PSA blood test include:

  • Multiple punctures to find the proper vein
  • Excessive bleeding
  • Feeling lightheaded or dizzy
  • Infection 
  • Hematoma (accumulation of blood under the skin)